Genetic approaches to metabolic bone diseases

Metabolic bone diseases: an overview.

Strategic approaches to unraveling genetic causes of cardiovascular diseases.

DNA sequence variants are major components of the "causal field" for virtually all medical phenotypes, whether single gene familial disorders or complex traits without a clear familial aggregation. The causal variants in single gene disorders are necessary and sufficient to impart large effects. In contrast, complex traits are attributable to a much more complicated network of contributory comp...

[Histologic diagnosis of metabolic bone diseases: bone histomorphometry].

Histomorphometry or quantitative histology is the analysis on histologic sections of bone resorption parameters, formation and structure. It is the only technique that allows a dynamic evaluation of the activity of bone modelling after labelling with tetracycline. Moreover, the new measurement procedures through the use of the computer allow an assessment of bone microarchitecture too. Histomor...

Using Mobile Health to Improve Genetic and Heart Diseases Prediction

Introduction: Mobile personal health are a rapidly growing area of health information technology. Mobile personal health users are able to manage their own health data and communicate with doctors in order to improve healthcare quality and efficiency. In recent years, information and communication technologies improvements, along with mobile Internet, offering anywhere and anytime connectivity,...

Thematic review series: systems biology approaches to metabolic and cardiovascular disorders. Proteomics approaches to the systems biology of cardiovascular diseases.

Proteins play a central role in a systems view of biologic processes. This review provides an overview of proteomics from a systems perspective. We survey the key tools and methodologies used, present examples of how these are currently being used in the systems biology context, and discuss future directions.